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NEW YORK – Some children get severely obese because they lack particular chunks of DNA, which kicks their hunger into overdrive, researchers report.
The British researchers checked the DNA of 300 children who’d become very fat, on the order of 220 pounds by age 10. They looked for deletions or extra copies of DNA segments.
They found evidence that several rare deletions may promote obesity, including one kind they studied further and found in less than 1 percent of about 1,200 severely obese children.
That deletion, on chromosome 16, apparently causes trouble because it removes a gene that the brain needs to respond to the appetite-controlling hormone leptin, said Dr. Sadaf Farooqi of Cambridge University.
In her study, children with a chromosome 16 DNA deletion “have a very strong drive to eat,” said Farooqi, who co-led the research. “They’re very, very hungry, they always want to eat.”
The work, reported online Sunday by the journal Nature, has already produced a real-world payoff. Farooqi said four children with the chromosome 16 deletion had drawn the attention of British child welfare authorities, who blamed the parents for overfeeding them.
“We were able to intervene” and get the parents of two children off the hook, and the other two cases are under discussion, she said.
That’s happened before when the scientists uncovered genetic causes for severe childhood obesity, she said.
“It’s a slightly unusual outcome of our research, but one we think is very important,” she said.
While scientists had previously discovered particular genes that promote obesity when damaged, the new work looked at larger chunks of DNA that can span several genes. The chromosome 16 deletion includes nine genes.
Eric Ravussin, an obesity expert at the Pennington Biomedical Research Center in Baton Rouge, La., who wasn’t involved in the study, said the work provides “a gold mine of information.” That’s because it identifies specific chromosome areas that scientists can explore to discover obesity-related genes, he said.

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COLUMBUS, Ohio (AP)—Ohio State star Evan Turner will miss 8 weeks after breaking bones in his back when he fell while dunking during Saturday’s game against Eastern Michigan.
Initial X-rays indicated no serious injuries, but Buckeyes athletic trainer Vince O’Brien said later tests found transverse process fractures of the second and third lumbar vertebra of Turner’s spine.
“My primary concern right now is Evan’s long-term health and well-being,” said Ohio State coach Thad Matta. “Evan was to this point in the season the best player in college basketball. We have been through tough situations before and our guys will regroup and prepare for the rest of our season starting with Butler next week in Indianapolis.”
The injury occurred after the junior swingman drove the lane and was fouled going up for a dunk with 13:27 left in the first half of the No. 15 Buckeyes’ game against Eastern Michigan.
Turner missed the dunk and hung on the rim with his feet flying into a nearly horizontal position, before falling on his back under the basket. He spent several minutes on the floor before walking with help to the locker room.
The Buckeyes (7-1), leading 15-5 at the time of the spill, went on to a 111-60 victory.
Turner, who came into the game averaging 20.6 points and 12.9 rebounds, was taken to The Ohio State University Medical Center for X-rays of his lower back. Initial tests showed no broken bones or substantial damage, but Matta said Turner would undergo more intensive tests before leaving the hospital. That is when the spinal breaks were noticed.
After the game, Matta said it appeared Turner would be fine.
“Everything looked good on the X-ray,” Matta said. “I haven’t seen the fall yet, but we’re obviously thinking about him and hoping that everything’s going to be OK.”
Turner’s injury marks the second year in a row at almost the same point in the season that one of the Buckeyes’ top players has been sidelined.
Last season, David Lighty, the team captain and most experienced player, broke his foot in the seventh game and missed the rest of the season. The Buckeyes, with Turner playing an increasingly larger role, went 22-11 before losing in the first round of the NCAA tournament.
Turner’s stock rose so high that he considered jumping to the NBA after the season, but elected to return. He recorded two triple doubles in Ohio State’s first five games—the second and third triple-doubles ever for a Buckeye.
Ohio State is off the next week for final exams and will play next at Butler on Saturday.

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PHILADELPHIA (AP)—Placido Polanco(notes) is putting aside his Gold Glove and switching positions to have a chance at winning a championship.
Polanco returned to the Philadelphia Phillies on Thursday, agreeing to an $18 million, three-year contract.
The 34-year-old free agent won Gold Gloves at second base for the Detroit Tigers in 2007 and this year, but will shift to third base, which hasn’t been his primary position since 2002. He replaces Pedro Feliz(notes), who became a free agent after the Phillies declined his $5.5 million option.
“I always wanted to be here, I never wanted to leave,” Polanco said. “One of the reasons I wanted to come back is because it’s pretty obvious the team is committed to winning. And I want to win. That’s it. They asked me if I was willing to play another position and I was like, ‘Sure.’ I can play third base. I played in college, in St. Louis and I also played some third here. I feel pretty confident about it.”
Polanco first joined the Phillies in the trade that sent Scott Rolen(notes) to St. Louis in July 2002. He hit .297 with 38 homers and 160 RBIs in parts of four seasons in Philadelphia. Once Chase Utley(notes) become the regular second baseman, Polanco’s role was reduced. He was traded to Detroit in June 2005 for reliever Ugueth Urbina and infielder Ramon Martinez(notes).
Polanco batted .285 for the Tigers last season with 31 doubles, 10 homers and 72 RBIs. He hit .341 and made the All-Star team in 2007.
“For him to come back to Philadelphia to change positions, it’s just one of the things he’s about,” Phillies general manager Ruben Amaro Jr. said. “He’s not only a tremendous professional and a championship-type player, but he’s a championship-type person, and that’s what we’re trying to do here, bring championship-type people, both talent-wise and personnel-wise.”
Polanco gets a $500,00 signing bonus, $5 million next season, $5.25 million in 2011 and $6.25 million in 2012. The deal includes a $5.5 million mutual option for 2013 with a $1 million buyout.
“The Phillies were always my first choice,” he said. “I played here, I know most of the guys here, I know the city. And they have a pretty good team that’s committed to win. I thank all of the other teams that expressed interest in me, but the Phillies were always my first choice.”
Polanco is a .303 hitter with 90 homers, 579 RBIs and 71 stolen bases in 12 seasons.
He joins a potent lineup that features five All-Stars—Utley, Shane Victorino(notes), Ryan Howard(notes), Jayson Werth(notes) and Raul Ibanez(notes)—and former MVP Jimmy Rollins(notes). He’s an ideal No. 2 hitter, but that’s been Victorino’s spot in the order.
“I want to win and you look around and we have a lot of great players,” Polanco said. “It seems like you could flip this lineup around and it would still be good, you know? Whatever Charlie wants me to do, I’d be more than happy to do it. I just know everyone here plays to win. Chase, Victorino, Rollins, Howard, everybody.”
The NL champions also agreed to a $750,000, one-year contract with infielder Juan Castro(notes), who hit .277 with one home run and nine RBIs in 57 games for the Los Angeles Dodgers last season.
The 37-year-old Castro replaces utilityman Eric Bruntlett(notes), who became a free agent. Castro made 19 starts at shortstop, eight at second base and two at third base, while also appearing in left field for two games.
Castro’s contract includes a $700,000 salary next year, and the deal has a $750,000 club option for 2011 with a $50,000 buyout.
“In Juan Castro, we have a versatile guy who can play multiple positions and is coming off a year in which he swung the bat fairly well,” Amaro said. “We’re very happy to add him to our club, as he will give Charlie options.”

PITTSBURGH (AP)—Ben Roethlisberger(notes) was “hurt” by teammate Hines Ward’s(notes) remarks questioning why a concussion kept him out of an important game against the Ravens. But the Steelers quarterback now agrees he shouldn’t have played.
Roethlisberger patched up his relationship with Ward during a phone call Monday, and the two have since moved on to Sunday’s game against Oakland.
“He reached out to me and I told him I was just hurt more than anything else,” Roethlisberger said Thursday. “You know, we got over it, moved past it and now we’re preparing.”
Ward apologized separately to Roethlisberger and the Steelers (6-5), saying he spoke out of frustration soon after learning the quarterback wouldn’t play in the 20-17 overtime loss in Baltimore. Ward didn’t know at the time of the interview that a team doctor recommended that Roethlisberger not play due to post-concussion headaches.
Roethlisberger received at least his fourth concussion since 2006 the previous week in Kansas City.
The quarterback said he was “in shock” when coach Mike Tomlin unexpectedly told him the day before the game he wouldn’t play. Now that he’s had time to consider the reasons for the benching, Roethlisberger said the move made sense.
“(I) respected what they said,” Roethlisberger said. “You do have to think about your future and your family. It’s not fun, but you can get knee replacement surgery, you can have rotator cuff surgeries, but you can’t get a new brain.”
Roethlisberger was seriously injured during a June 2006 motorcycle accident in which he received a concussion and numerous other facial injuries, including a broken jaw. He still has five plates in his head resulting from that crash.
“A lot of people forget the accident that I had,” Roethlisberger said. “They (the doctors) remembered that. It was life-threatening.”
Roethlisberger said he hasn’t had a recurrence of the headaches brought on by physical activity that occurred following three practices last week.
“I feel great. I’m ready to go … ready to rock and roll.”

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ATLANTA (AP)—Roddy White(notes) looks forward to seeing Michael Vick(notes). Just don’t expect the Falcons receiver to don another T-shirt showing his support for No. 7.
“I’ve got to be locked in,” White said Wednesday, breaking into a hearty laugh. “This is a big game for us.”
No one is quite sure what kind of reception Michael Vick will get when he returns to the Georgia Dome for the first time since serving 18 months in federal prison for dogfighting. After being out of the league for two seasons, the former Falcons quarterback is now a little-used backup for the Philadelphia Eagles (7-4), who face the Falcons (6-5) Sunday in a crucial matchup of NFC playoff contenders.
Far from the spare part he is now, Vick was one of the league’s most dynamic players during his six years with the Falcons, leading the team to the brink of the Super Bowl after the 2004 season. Some Atlanta fans continue to wear his No. 7 jersey to games, and one group is even planning a welcome home rally for him outside the stadium.
Of course, there will likely be plenty of boos from fans still appalled at the heinous crimes he committed against animals and how much he hurt the franchise that gave him the richest contract in NFL history.
“I don’t really know what’s going to happen,” Vick said Wednesday at the Eagles’ training complex. “I know I still enjoy the city. I’ll never forget the fans. I’ll always be true to them. Who knows? I look forward to going back and being in that stadium. That’s going to be like a dream come true, even though I’m on the opposite side.”
Back in 2007, on the very day Vick was sentenced to prison, the Falcons played a Monday night game against the New Orleans Saints. White paid tribute to his disgraced friend by wearing a “Free Mike Vick” T-shirt under his jersey, which he pulled up after scoring a touchdown so a national television audience could see the handwritten message—a stunt that drew a $10,000 fine from the NFL.
White has no such plans for Sunday, and there’s been so much turnover on the Falcons’ roster that only a handful of players who took the field during Vick’s tenure are still around. Among the 22 starters, a mere seven are holdovers from No. 7’s era.
“I haven’t been thinking about it. It doesn’t matter to me,” said tight end Tony Gonzalez(notes), who’s in his first season with the team. “I know he’s coming back. I’m sure there are some people who are going to welcome him and some people that are not. That’s not my deal. I’m out there to play football.”
But Vick still has friends on the team, including White and another receiver, Brian Finneran(notes). Both have stayed in contact with the ex-Atlanta quarterback.
“We’re always texting back and forth,” White said. “It’s more about life, what’s going on, things like that. It’s nothing football related.”
Have they exchange messages this week? Sure.
“I texted him and said, ‘I look forward to seeing you on Sunday,”’ White said. “He told me, ‘Good luck, get out there and do your thing.’ I think I’m going to text him today and ask for the game plan.”
The receiver was only kidding, of course, but his feelings for Vick are genuine. He’s not defending what his former teammate did away from the field, only remembering the good times they had together.
“He welcomed me here, took me under his wing, got me the ball. How could I be mad at the guy?” White asked. “We’re cool, man. Right before he had to go off and do his thing (prison sentence), we used to hang out. We developed a great relationship. We’re still going to be friends, regardless of football.”
Vick also speaks from time to time with Falcons owner Arthur Blank, who supported his former star’s re-entry into the league and has continually said he would do anything to make sure he keeps his life on the right track, though he ruled out any chance of Vick ever returning to the Falcons.
“I’ll probably give him a call before I get down to Atlanta,” Vick said. “We still have that relationship. I always enjoy speaking with Mr. Blank. He’s a great guy. He’s awesome. He’s done a lot of great things for me, things I’ll never forget. He’s a special person, a person who holds a special place in my heart.”
Atlanta broke all ties with its former franchise player by drafting Matt Ryan(notes) with the No. 3 overall pick in 2008. The rookie won the starting job right away and led the Falcons too a surprising playoff berth.
In an interesting twist, Ryan won’t be playing Sunday because of a toe injury and Vick figures to get only a few plays for the Eagles, if his role up to now is any indication. The three-time Pro Bowler has 15 carries for 65 yards and is 3 of 9 passing for 6 yards. He has yet to score his first post-prison touchdown though he came close in last weekend’s win over the Redskins, breaking off a 4-yard run to the 1.
Vick would love a chance to make up for his last game at the Georgia Dome, which was Christmas Eve 2006. He had one of the worst games of his Falcons career, completing 9 of 20 passes for 109 yards with two interceptions and running four times for 32 yards in a 10-3 loss to Carolina.
But Vick knows he’s not likely to get on the field for more than a few snaps — quite a letdown for a guy who once dominated in the dome.
“This week is going to be a little tougher than average because I played in that stadium,” Vick said. “That’s where I started my career, and I have so many great memories.”
He no longer has the ritzy house in a gated suburban community; that was put on the auction block after he went to prison. But Vick still has plenty of ties to Atlanta.
“The majority of my friends are still there in the city, and who knows if I get a chance to visit with a couple of them? My time is going to be very limited, so who knows?” Vick said.
“The primary focus is on the football game.”
AP Sports Writer Rob Maaddi in Philadelphia contributed to this report.

NFL teams now have new, stricter instructions for when players should be allowed to return to games or practices after head injuries, guidelines that go into effect this week.
In the latest step by the league to address a hot-button issue, commissioner Roger Goodell sent a memo to the 32 clubs Wednesday saying a player who gets a concussion should not return to action on the same day if he shows certain signs or symptoms.
Those include an inability to remember assignments or plays, a gap in memory, persistent dizziness, and persistent headaches.
The old standard, established in 2007, said a player should not be allowed to return to the same game if he lost consciousness.
Wednesday’s memo also says players “are to be encouraged to be candid with team medical staffs and fully disclose any signs or symptoms that may be associated with a concussion.”
Nearly one-fifth of 160 NFL players surveyed by The Associated Press from Nov. 2-15 replied that they have hidden or played down the effects of a concussion.
The new policy states, in part: “Once removed for the duration of a practice or game, the player should not be considered for return-to-football activities until he is fully asymptotic, both at rest and after exertion, has a normal neurological examination, normal neuropsychological testing, and has been cleared to return by both his team physician(s) and the independent neurological consultant.”
Teams were told this month they have to find an outside neurologist who can be consulted on concussions, and NFL spokesman Greg Aiello said this week the league is “very close” to having all of those independent doctors approved and in place.
Since last month’s congressional hearing on NFL head injuries, momentum has been building for changes in league policy. The revised return-to-play rules come about a week after Goodell sent a memo to clubs informing them that the two co-chairmen of the league’s concussions committee had resigned and that he has been looking into possible rule changes.
On Wednesday, word emerged that Cleveland Browns running back Jamal Lewis(notes) will miss Sunday’s game with an unspecified head injury, raising the possibility his NFL career is over. Lewis had previously said he would retire at the end of the season. His teammate, starting safety Brodney Pool(notes), got at least his fourth known concussion last weekend and is likely out for the year.
The two starting quarterbacks from last season’s Super Bowl—Pittsburgh’s Ben Roethlisberger(notes) and Arizona’s Kurt Warner(notes)—sat out last Sunday after saying during the week they planned to play despite getting head injuries the previous week.
“The evidence demonstrates that team medical staffs have been addressing concussions in an increasingly cautious and conservative way,” Goodell wrote in Wednesday’s memo. “This new return-to-play statement reinforces our commitment to advancing player safety. Along with improved equipment, better education, and rules changes designed to reduce impacts to the head, it will make our game safer for the men who play it, and set an important example for players at all levels of play.”